解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::An association was found earlier between the Ep(1) gene locus coding for an endopeptidase and the endosperm color gene Y(1) on chromosome 6 of Zea mays. By employing primary trisomics we have unequivocally placed the Ep(1) gene on chromosome 6, closely linked to the Y(1) locus. Additionally we describe new alleles at ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-08-01 00:00:00
abstract::Mutants resistant to selenomethionine were isolated, and their properties studied. Mapping studies indicate that the mutation sites are located near the eth-1(r) locus in linkage group I, about ten map units away from the mating type locus. The sites of new mutation are either allelic to or very close to eth-1(r). The...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-08-01 00:00:00
abstract::The Standard and Sex Ratio gene arrangements of the X chromosome of D. pseudobscura differ from each other in allele frequencies at the four X chromosome loci, esterase-5, adult acid phosphatase-6, phosphoglucomutase-1 and octanol dehydrogenase-3. The Standard arrangement which is the common arrangement in all populat...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-08-01 00:00:00
abstract::A model emphasizing the possible genetic role of tandem duplications of reverse repeats has been developed as an extension of Crick's (1971) general model for the chromosomes of higher organisms. Although developed initially (1) to explain why random differences in the control regions of individual gene loci might con...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-07-01 00:00:00
abstract::Salmonella typhimurium can normally use glycine as a serine source to support the growth of serine auxotrophs. This reaction was presumed to occur by the reversible activity of the enzyme, serine transhydroxymethylase (E. C. 2. 1. 2. 1; L-serine: tetrahydrofolic-5, 10 transhydroxymethylase), which is responsible for g...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-06-01 00:00:00
abstract::Significant correlations between allelic frequencies and environmental variables in a number of insect species have been demonstrated by multivariate techniques. Since many environmental variables show a strong relationship to geographic location and since gene flow between populations can also produce patterns of gen...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-05-01 00:00:00
abstract::Genetical and biochemical studies have been performed with revertants induced in a polyaromatic mutant (No. 58) in the arom gene cluster of Neurospora crassa. In addition to complete and partial revertants able to grow on minimal at both 25 degrees and 35 degrees , temperature-sensitive revertants capable of growth on...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-04-01 00:00:00
abstract::Hairpin-tail (T(hp)) is a new allele of brachyury on chromosome 17 (linkage group IX) of the mouse. The morphological effects in the heterozygote are on the notochord and the tail. The homozygous abnormal is unknown. T(hp) is unique in that the phenotype of the heterozygote seems to depend on the source of the T(hp) g...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-04-01 00:00:00
abstract::The genetic and environmental components of variance for two quantitative characters were measured in the descendants of Drosophila melanogaster populations which had been grown for several generations at densities of 100, 200, 300, and 400 eggs per vial. Populations subject to intermediate densities had a greater pro...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-03-01 00:00:00
abstract::Using a new model of isoalleles, extensive Monte Carlo experiments were performed to examine the pattern of allelic distribution in a finite population. In this model it was assumed that the set of allelic states is represented by discrete points on a one-dimensional lattice and that change of state by mutation occurs...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-03-01 00:00:00
abstract::In random mating autopolyploid populations which have not reached equilibrium, two alleles may be interdependent as a result of the phenomenon of gametic recombination, i.e. the maintenance through successive gamete generations of an association of two alleles from the same gamete in a source reference generation. Any...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-03-01 00:00:00
abstract::Complementation and polarity suppression data are interpreted in terms of the genetic structure of the maltose B region. It is proposed that this region comprises two divergent operons. One operon includes malK, a cistron involved in maltose permeation, and lamB the only known cistron specifically involved in lambda r...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-02-01 00:00:00
abstract::A continuing study of mortality rates among children born to survivors of the atomic bombings and a suitable group of controls has been updated; the average interval between birth and verification of death or survival is 17 years. The mortality experience is now based on 18,946 children liveborn to parents one or both...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-02-01 00:00:00
abstract::A multi-locus model for complete positive assortative mating is discussed. For a two-locus model, if the gene frequencies for the two loci are different, as they are likely to be, it is shown that in equilibrium the population is not composed of only two homozygous types, as is usually thought. The limiting distributi...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-12-01 00:00:00
abstract::Twelve laboratory populations of recently collected Drosophila willistoni were begun with different frequencies of alleles at three enzyme loci, six populations at 25 degrees and six at 19 degrees . Periodic sampling of the populations allowed monitoring of the frequency changes in allozymes over time.-At Lap-5 (a loc...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-11-01 00:00:00
abstract::The central and marginal populations of D. robusta differ greatly in the level of inversion polymorphism; the marginal populations are monomorphic or nearly so and the central populations are highly polymorphic. This paper presents the frequencies of alleles at forty gene loci in various populations of D. robusta, stu...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-10-01 00:00:00
abstract::The type of variegation of eyes of white-mottled mutants of D. hydei, either small-spotted or large-spotted, depends on the specific chromosome rearrangement involved. This distinction between mutants, though handsome, is not absolute because very seldomly small-spotted types do show a larger pigment aggregate and som...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-10-01 00:00:00
abstract::A spontaneous lethal mutation rate approximately twenty to thirty times greater than normal has been discovered in second and third chromosomes derived from an irradiated isogenic line and paired with marked inversion chromosomes. Mutations resulting in reductions of viability of varying magnitude short of complete le...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-09-01 00:00:00
abstract::Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-08-01 00:00:00
abstract::The isozymic patterns of tyrosine aminotransferase, NADP malate dehydrogenase, NADP isocitrate dehydrogenase, and tetrazolium oxidase were examined by starch-gel electrophoresis in Tetrahymena pyriformis, syngen 1. The genetics of the alleles controlling these enzymes was studied through a breeding program. Each enzym...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-08-01 00:00:00
abstract::Dimethylnitrosamine and diethylnitrosamine, two potent carcinogens, are nonmutagenic when tested directly in microorganisms. Likewise 1-naphthylamine and 2-naphthylamine are also nonmutagenic but the N-hydroxy derivatives are mutagenic in microorganisms. Apparently these compounds require metabolism to breakdown produ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-07-01 00:00:00
abstract::The level of activity of the enzyme glucose-6-phosphate dehydrogenase was determinel in flies having seven different chromosomic constitutions. All those having an integral number of chromosomes [XAA, XXAA, XAAA, XXAAA, and XXXAAA (X=Xchromosome, A=set of autosomes)] were found to have similar units of enzyme activity...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-06-01 00:00:00
abstract::In S. commune the frequency of recombination between the two subunits, alpha and beta, of the B incompatibility factor is genetically controlled. Analysis of the progeny obtained from crosses between high- and low-recombining strains indicates that the gene controlling recombination frequency in the B factor is linked...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-05-01 00:00:00
abstract::Host mutations in Escherichia coli K12 selected for the temperature-sensitive replication of the bacterial plasmid colicinogenic factor E(1) (ColE(1)) exhibit a pleiotropic effect with respect to the effect of the mutation on other extra-chromosomal elements. The mutations also vary with respect to the time of incubat...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-05-01 00:00:00
abstract::THE FOLLOWING MODELS ARE CONSIDERED FOR THE GENETIC DETERMINATION OF QUANTITATIVE TRAITS: segregation at one locus, at two linked loci, at any number of equal and additive unlinked loci, and at one major locus and an indefinite number of equal and additive loci. In each case an appropriate likelihood is given for data...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-04-01 00:00:00
abstract::The F(1) hybrids of Nicotiana suaveolens (subgenus Petunioides, 2n = 32) and N. glutinosa (subgenus Tabacum, 2n = 24), were examined during their development, from seedlings to mature plants. It was observed that in the hybrids, there was a progressive change of dominant N. glutinosa morphological characteristics towa...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-04-01 00:00:00
abstract::This paper presents the results of a study of linkage disequilibrium between five polymorphic enzyme genes located on chromosome 3 of D. melanogaster. Three sets of chromosomes were examined: two represented samples from successive years of the same natural population, and one came from a large laboratory population. ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-02-01 00:00:00
abstract::Of 313 motility-deficient mutants isolated from an LT2 his(amber) strain fixed in phase 1 by gene vh2(-), 25 regained motility when amber or ochre suppressors were introduced, in F' factors or by transduction. The fla mutants (23 amber, 1 ochre) fell in complementation groups A, B, C, F, K, a new group, M, and at leas...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-02-01 00:00:00
abstract::Considering a random mating population of finite size, the variance of the number of loci having a given gene frequency was derived under the assumption of a steady flux of mutations. The variance of average heterozygosity among populations was also derived under the same assumption. It was shown that these variances ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-02-01 00:00:00
abstract::The time of the pre-meiotic S-period was determined by (32)P incorporation in synchronously germinating zygospores of Chlamydomonas reinhardi at six and one-half to seven hours after the beginning of germination. Phenethyl alcohol treatment caused death of zygospores at a period one hour before the S-period, and also ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-01-01 00:00:00
abstract::Phenoxazinone synthetase, which catalyzes the condensation of 3-hydroxykynurenine to xanthommatin, the brown eye pigment of Drosophila, is shown to exist in association with a particle which resembles the cytologically defined Type I pigment granule. Several classical eye color mutants (v, cn, st, ltd, cd, w), includi...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-01-01 00:00:00
abstract::Data for Apis mellifera indicate that the P-3 proteins and one esterase enzyme are controlled by two genes, P-3 and Est, with two alleles each. The frequency of the P-3 alleles is different in the two subspecies (adansonii and ligustica), that for P-3(F) in Italian bees being 46.9% and in African 0.5%. The frequency o...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-12-01 00:00:00
abstract::A computer system for the storage and processing of microbial meiotic data has been developed. Based on the language Fortran 4, the program retrieves relevant data and determines the order, map distances, and coefficient of coincidence for any three-gene group. Meiotic data from Aspergillus nidulans were used to test ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-12-01 00:00:00
abstract::The change in frequencies of D. melanogaster and D. simulans in competition experiments was used to measure the effect of radiation on the fitness of a population. A dose of 250 or 500 rads given to the males of highly inbred lines of D. simulans at the beginning of competition and every three weeks thereafter increas...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-11-01 00:00:00
abstract::The satellite DNA's from the embryos of five species of Drosophila (D. melanogaster, D. simulans, D. nasuta, D. virilis and D. hydei) have been analyzed for the presence of closed circular duplex DNA molecules, as determined by CsCl-EBr gradients. Circular DNA molecules were found in every species but D. melanogaster....
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-11-01 00:00:00
abstract::Tetrazolium oxidase from the blood and liver of rainbow trout was found to be genetically polymorphic. The inheritance pattern of the liver enzyme was compatible only with a one locus-two allele hypothesis. The enzymes in the blood while having an electrophoretically identical polymorphism could differ genotypically f...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-10-01 00:00:00
abstract::The behaviour of two "meiotic drive" systems, Segregation-Distorter (SD) and the sex chromosome sc(4)sc(8) has been examined in the same meiocyte. It has been found that the two systems interact in a specific way. When the distorting effects of SD and sc(4)sc(8) are against each other, there is no detectable interacti...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-09-01 00:00:00
abstract::Zymograms were analyzed of a number of Triticum aestivum derivatives which incorporated a segment of the Aegilops umbellulata chromosome bearing resistance to leaf rust. Evidence has been presented which suggests that genes involved in the production of two peroxidases and a single peptidase are located on the short a...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-09-01 00:00:00
abstract::Natural populations of Daphnia magna have been found which are polymorphic for electrophoretic variants of supernatant malic dehydrogenase, esterase, and alkaline phosphatase. Using these enzyme variants as genetic markers it has been possible to demonstrate the absence of recombination during parthenogenetic reproduc...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-08-01 00:00:00
abstract::A mutant strain of Chlamydomonas reinhardi which is UV sensitive as a result of a single-gene chromosomal mutation has also been found to exhibit reduced recombination. In crosses homozygous for the mutant allele, a reduction in recombination frequency was demonstrated in two different linkage groups and in three diff...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-06-01 00:00:00